Structure and activation mechanism of the BBSome membrane protein trafficking complex

Structure and activation mechanism of the BBSome membrane protein trafficking complex

Bardet-Biedl syndrome (BBS) is a currently incurable ciliopathy caused by the failure to correctly establish or maintain cilia-dependent signaling pathways. Eight proteins associated with BBS assemble into the BBSome, a key regulator of the ciliary membrane proteome. We report the electron cryomicro...

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Bibliographic Details
Main Authors: Sandeep K Singh, Miao Gui, Fujiet Koh, Matthew CJ Yip, Alan Brown
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
Bos taurus
cilia
BBSome
intraflagellar transport
protein trafficking
cryo-EM
Online Access:https://elifesciences.org/articles/53322

Internet

https://elifesciences.org/articles/53322

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