JNK and macroautophagy activation by bortezomib has a pro-survival effect in primary effusion lymphoma cells.

Understanding the mechanisms of autophagy induction and its role during chemotherapeutic treatments is of fundamental importance in order to manipulate it to improve the outcome of chemotherapy. In particular whether the bortezomib-induced autophagy plays a pro-survival or pro-death role is still co...

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Bibliographic Details
Main Authors: Marisa Granato, Roberta Santarelli, Lavinia V Lotti, Livia Di Renzo, Roberta Gonnella, Alessia Garufi, Pankaj Trivedi, Luigi Frati, Gabriella D'Orazi, Alberto Faggioni, Mara Cirone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3784388?pdf=render