Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk

We know a large number of risk SNPs for schizophrenia, but little about how these SNPs contribute to the disorder. Here, the authors use functional genomics to identify risk SNPs that disrupt transcription factor binding and validate the regulatory effects of the transcription factor binding-disrupt...

Full description

Bibliographic Details
Main Authors: Yongxia Huo, Shiwu Li, Jiewei Liu, Xiaoyan Li, Xiong-Jian Luo
Format: Article
Language:English
Published: Nature Publishing Group 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08666-4