Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice

Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice

Host genetic variation is known to contribute to differential pathogenesis following infection. Mouse models allow direct assessment of host genetic factors responsible for susceptibility to Severe Acute Respiratory Syndrome coronavirus (SARS-CoV). Based on an assessment of early stage lines from th...

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Bibliographic Details
Main Authors: Lisa E. Gralinski, Vineet D. Menachery, Andrew P. Morgan, Allison L. Totura, Anne Beall, Jacob Kocher, Jessica Plante, D. Corinne Harrison-Shostak, Alexandra Schäfer, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Ralph S. Baric
Format: Article
Language:English
Published: Oxford University Press 2017-06-01
Series:G3: Genes, Genomes, Genetics
Subjects:
SARS-CoV
Collaborative Cross
F2
Ticam2
host susceptibility genes
Multi-parent Advanced Generation Inter-Cross (MAGIC)
multiparental populations
MPP
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.041434

Internet

http://g3journal.org/lookup/doi/10.1534/g3.117.041434

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