TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of Activin signals.

TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of Activin signals.

Lymphatic systems play important roles in the maintenance of fluid homeostasis and undergo anatomical and physiological changes during inflammation and aging. While lymphatic endothelial cells (LECs) undergo mesenchymal transition in response to transforming growth factor-β (TGF-β), the molecular me...

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Bibliographic Details
Main Authors: Yasuhiro Yoshimatsu, Shiori Kimuro, Joris Pauty, Kazuki Takagaki, Sanae Nomiyama, Akihiko Inagawa, Kentaro Maeda, Katarzyna A Podyma-Inoue, Kentaro Kajiya, Yukiko T Matsunaga, Tetsuro Watabe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0232356

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https://doi.org/10.1371/journal.pone.0232356

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