Design and Validation of Linkers for Site-Specific Preparation of Antibody–Drug Conjugates Carrying Multiple Drug Copies per Cysteine Conjugation Site

Design and Validation of Linkers for Site-Specific Preparation of Antibody–Drug Conjugates Carrying Multiple Drug Copies per Cysteine Conjugation Site

First-generation cysteine-based site-specific antibody–drug conjugates (ADCs) are limited to one drug per cysteine. However, certain applications require a high drug to antibody ratio (DAR), such as when low-potency payloads are used. Higher drug load can be achieved using classical cysteine conjuga...

Full description

Bibliographic Details
Main Authors: Amit Kumar, Shenlan Mao, Nazzareno Dimasi, Changshou Gao
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
antibody–drug conjugate (ADC)
drug to antibody ratio (DAR)
heterofunctional linker
site-specific conjugation
cysteine conjugation
branched linker
Online Access:https://www.mdpi.com/1422-0067/21/18/6882

Internet

https://www.mdpi.com/1422-0067/21/18/6882

Similar Items