Development of Novel Intramolecular FRET-Based ABC Transporter Biosensors to Identify New Substrates and Modulators

Multidrug resistance protein 1 (MRP1) can efflux a wide variety of molecules including toxic chemicals, drugs, and their derivatives out of cells. Substrates of MRP1 include anti-cancer agents, antibiotics, anti-virals, anti-human immunodeficiency virus (HIV), and many other drugs. To identify novel...

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Bibliographic Details
Main Authors: Bremansu Osa-Andrews, Kee W. Tan, Angelina Sampson, Surtaj H. Iram
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Pharmaceutics
Subjects:
Online Access:http://www.mdpi.com/1999-4923/10/4/186