Utility of the succinate:fumarate ratio for assessing SDH dysfunction in different tumor types

Utility of the succinate:fumarate ratio for assessing SDH dysfunction in different tumor types

Objective: Mutations of genes encoding the four subunits of succinate dehydrogenase (SDH) have been associated with pheochromocytoma and paraganglioma (PPGLs), gastrointestinal stromal tumors (GISTs) and renal cell carcinomas (RCCs). These tumors have not been characterized in a way that reflects se...

Full description

Bibliographic Details
Main Authors: Edward Kim, Michael JP. Wright, Loretta Sioson, Talia Novos, Anthony J. Gill, Diana E. Benn, Christopher White, Trisha Dwight, Roderick J. Clifton-Bligh
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
Succinate dehydrogenase deficiency
Mass spectrometry
Pheochromocytoma and paraganglioma
Gastrointestinal stromal tumor
Renal cell carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426916301288

Internet

http://www.sciencedirect.com/science/article/pii/S2214426916301288

Similar Items