Distinct Patterns of Myeloid Cell Infiltration in Patients With hrHPV-Positive and hrHPV-Negative Penile Squamous Cell Carcinoma: The Importance of Assessing Myeloid Cell Densities Within the Spatial Context of the Tumor

Distinct Patterns of Myeloid Cell Infiltration in Patients With hrHPV-Positive and hrHPV-Negative Penile Squamous Cell Carcinoma: The Importance of Assessing Myeloid Cell Densities Within the Spatial Context of the Tumor

Comprehensive analysis of tumor infiltrating myeloid cells in the tumor microenvironment of penile squamous cell carcinoma (PSCC) is lacking. In this retrospective study, for the first time, PSCC resection specimens (N = 103) were annotated into the following compartments: intratumoral tumor (IT Tum...

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Bibliographic Details
Main Authors: Tynisha S. Rafael, Hielke M. de Vries, Sarah R. Ottenhof, Ingrid Hofland, Annegien Broeks, Jeroen de Jong, Elise Bekers, Simon Horenblas, Renée X. de Menezes, Ekaterina S. Jordanova, Oscar R. Brouwer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
penile cancer
human papillomavirus
squamous cell carcinoma
tumor infiltrating myeloid cells
image analysis
compartments
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.682030/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.682030/full

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