Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice.

Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice.

Diabetic kidney disease (DKD) is characterized by progressive glomerulosclerosis (GS). ROP mice have a sclerosis-prone phenotype. However, they develop severe, rapidly progressive GS when rendered diabetic. Since GS also develops in aged C57Bl6 mice, and can be reversed using bone marrow from young...

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Bibliographic Details
Main Authors: Fabrizio Grosjean, Elena M Yubero-Serrano, Feng Zheng, Vittoria Esposito, Shobha Swamy, Sharon J Elliot, Weijing Cai, Helen Vlassara, Fadi Salem, Gary E Striker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6155507?pdf=render

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http://europepmc.org/articles/PMC6155507?pdf=render

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