Substrate Specificity Analysis of Dihydrofolate/Dihydromethanopterin Reductase Homologs in Methylotrophic α-Proteobacteria

Substrate Specificity Analysis of Dihydrofolate/Dihydromethanopterin Reductase Homologs in Methylotrophic α-Proteobacteria

Methane-producing archaea and methylotrophic bacteria use tetrahydromethanopterin (H4MPT) and/or tetrahydrofolate (H4F) as coenzymes in one-carbon (C1) transfer pathways. The α-proteobacterium Methylobacterium extorquens AM1 contains a dihydromethanopterin reductase (DmrA) and two annotated dihydrof...

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Bibliographic Details
Main Authors: Mark Burton, Chidinma Abanobi, Kate Tzu-Chi Wang, Yihua Ma, Madeline E. Rasche
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Microbiology
Subjects:
methylotrophic bacteria
dihydrofolate reductase
dihydromethanopterin reductase
methanopterin
one-carbon transfer
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02439/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02439/full

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