Beta-aminoisobutyric acid is released by contracting human skeletal muscle and lowers insulin release from INS-1 832/3 cells by mediating mitochondrial energy metabolism

Beta-aminoisobutyric acid is released by contracting human skeletal muscle and lowers insulin release from INS-1 832/3 cells by mediating mitochondrial energy metabolism

Aims/hypothesis: This study aimed to examine if beta-aminoisobutyric acid (BAIBA) is (i) secreted by skeletal muscle in humans during exercise, (ii) associated with insulin secretory function in vivo, and (iii) directly linked with acute glucose-mediated insulin release by pancreatic beta cells in v...

Full description

Bibliographic Details
Main Authors: Jonathan P. Barlow, Kristian Karstoft, Andreas Vigelsø, Martin Gram, Jørn W. Helge, Flemming Dela, Kirk Pappan, Donna O’Neil, Warwick Dunn, Thomas P.J. Solomon
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Metabolism Open
Subjects:
Exercise
Muscle contraction
Myokine
Type 2 diabetes
Glucolipotoxicity
Pancreatic beta-cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2589936820300335

Internet

http://www.sciencedirect.com/science/article/pii/S2589936820300335

Similar Items