XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response

XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response

Summary: Transcription factor XBP1s, activated by endoplasmic reticulum (ER) stress in a dose-dependent manner, plays a central role in adaptive unfolded protein response (UPR) via direct activation of multiple genes controlling protein refolding. Here, we report that elevation of ER stress above a...

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Bibliographic Details
Main Authors: Emily E. Fink, Sudha Moparthy, Archis Bagati, Anna Bianchi-Smiraglia, Brittany C. Lipchick, David W. Wolff, Matthew V. Roll, Jianmin Wang, Song Liu, Andrei V. Bakin, Eugene S. Kandel, Ann-Hwee Lee, Mikhail A. Nikiforov
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718314438

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http://www.sciencedirect.com/science/article/pii/S2211124718314438

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