Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances

Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances

Chemical synaptic transmission relies on the Ca2+-induced fusion of transmitter-laden vesicles whose coupling distance to Ca2+ channels determines synaptic release probability and short-term plasticity, the facilitation or depression of repetitive responses. Here, using electron- and super-resolutio...

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Bibliographic Details
Main Authors: Janus RL Kobbersmed, Andreas T Grasskamp, Meida Jusyte, Mathias A Böhme, Susanne Ditlevsen, Jakob Balslev Sørensen, Alexander M Walter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
synaptic transmission
short-term plasticity
vesicular release sites
ca2+ channels
mathematical modelling
stochastic simulation
Online Access:https://elifesciences.org/articles/51032

Internet

https://elifesciences.org/articles/51032

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