New surfactant with SP-B and C analogs gives survival benefit after inactivation in preterm lambs.

BACKGROUND: Respiratory distress syndrome in preterm babies is caused by a pulmonary surfactant deficiency, but also by its inactivation due to various conditions, including plasma protein leakage. Surfactant replacement therapy is well established, but clinical observations and in vitro experiments...

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Main Authors: Matthias Seehase, Jennifer J P Collins, Elke Kuypers, Reint K Jellema, Daan R M G Ophelders, Olga L Ospina, J Perez-Gil, Federico Bianco, Raffaella Garzia, Roberta Razzetti, Boris W Kramer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3473048?pdf=render