Excitotoxicity through Ca2+-permeable AMPA receptors requires Ca2+-dependent JNK activation

Excitotoxicity through Ca2+-permeable AMPA receptors requires Ca2+-dependent JNK activation

The GluA4-containing Ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors (Ca-AMPARs) were previously shown to mediate excitotoxicity through mechanisms involving the activator protein-1 (AP-1), a c-Jun N-terminal kinase (JNK) substrate. To further investigate JNK involveme...

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Bibliographic Details
Main Authors: M. Vieira, J. Fernandes, A. Burgeiro, G.M. Thomas, R.L. Huganir, C.B. Duarte, A.L. Carvalho, A.E. Santos
Format: Article
Language:English
Published: Elsevier 2010-12-01
Series:Neurobiology of Disease
Subjects:
AMPA receptors
AP-1 transcription factor
Calcium channels
Cell death
Excitotoxicity
Transient global ischemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110002639

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http://www.sciencedirect.com/science/article/pii/S0969996110002639

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