Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.

Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.

HIV sequence diversity and potential decoy epitopes are hurdles in the development of an effective AIDS vaccine. A DNA vaccine candidate comprising of highly conserved p24(gag) elements (CE) induced robust immunity in all 10 vaccinated macaques, whereas full-length gag DNA vaccination elicited respo...

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Bibliographic Details
Main Authors: Viraj Kulkarni, Antonio Valentin, Margherita Rosati, Candido Alicea, Ashish K Singh, Rashmi Jalah, Kate E Broderick, Niranjan Y Sardesai, Sylvie Le Gall, Beatriz Mothe, Christian Brander, Morgane Rolland, James I Mullins, George N Pavlakis, Barbara K Felber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3900501?pdf=render

Internet

http://europepmc.org/articles/PMC3900501?pdf=render

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