Targeting intrinsic RIG-I signaling turns melanoma cells into type I interferon-releasing cellular antitumor vaccines

Targeting intrinsic RIG-I signaling turns melanoma cells into type I interferon-releasing cellular antitumor vaccines

Resistance to cell death and evasion of immunosurveillance are major causes of cancer persistence and progression. Tumor cell-intrinsic activation of the RNA receptor retinoic acid-inducible gene-I (RIG-I) can trigger an immunogenic form of programmed tumor cell death, but its impact on antitumor re...

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Bibliographic Details
Main Authors: Sarah Bek, Florian Stritzke, Alexander Wintges, Tatiana Nedelko, Daniel F.R. Böhmer, Julius C. Fischer, Tobias Haas, Hendrik Poeck, Simon Heidegger
Format: Article
Language:English
Published: Taylor & Francis Group 2019-04-01
Series:OncoImmunology
Subjects:
immunogenic cell death
pattern recognition receptors
nucleic acid receptors
rig-i
anticancer vaccine
dendritic cells
tumor immunotherapy
personalized medicine
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1570779

Internet

http://dx.doi.org/10.1080/2162402X.2019.1570779

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