An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution

An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution

Type 3 innate lymphoid cells (ILC3) are involved in maintaining gut immune homeostasis. Here the authors identify a circular RNA, circKcnt2, to be induced in ILC3s from inflamed gut, yet circKcnt2 deletion aggravates mouse experimental colitis, thereby implicating circKcnt2 as a potential feedback r...

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Bibliographic Details
Main Authors: Benyu Liu, Buqing Ye, Xiaoxiao Zhu, Liuliu Yang, Huimu Li, Nian Liu, Pingping Zhu, Tiankun Lu, Luyun He, Yong Tian, Zusen Fan
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17944-5

Internet

https://doi.org/10.1038/s41467-020-17944-5

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