Clonal progression during the T cell-dependent B cell antibody response depends on the immunoglobulin DH gene segment repertoire.

Clonal progression during the T cell-dependent B cell antibody response depends on the immunoglobulin DH gene segment repertoire.

The diversity of the third complementarity determining region of the Ig H chain is constrained by natural selection of immunoglobulin diversity (DH) sequence. To test the functional significance of this constraint in the context of thymus-dependent (TD) immune responses, we immunized BALB/c mice wi...

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Bibliographic Details
Main Authors: Ahmad eTrad, Radu Iulian Tanasa, Hans eLange, Michael eZemlin, Harry W Schroeder, Hilmar eLemke
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Immunology
Subjects:
Antibodies
B cells
rodent
Class switch recombination
CDR-H3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00385/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00385/full

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