Hexokinase 2 is dispensable for T cell-dependent immunity

Hexokinase 2 is dispensable for T cell-dependent immunity

Abstract Background T cells and cancer cells utilize glycolysis for proliferation. The hexokinase (1–4) family of enzymes catalyze the first step of glycolysis. Hexokinase 2 (HK2) is one of the most highly upregulated metabolic enzymes in both cancer and activated T cells. HK2 is required for the de...

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Bibliographic Details
Main Authors: Manan M. Mehta, Samuel E. Weinberg, Elizabeth M. Steinert, Krishan Chhiba, Carlos Alberto Martinez, Peng Gao, Harris R. Perlman, Paul Bryce, Nissim Hay, Navdeep S. Chandel
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Cancer & Metabolism
Subjects:
Hexokinase 2
T cells
Tregs
Leukemia
Colitis
LCMV
Online Access:http://link.springer.com/article/10.1186/s40170-018-0184-5

Internet

http://link.springer.com/article/10.1186/s40170-018-0184-5

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