A Glycoengineered Interferon-β Mutein (R27T) Generates Prolonged Signaling by an Altered Receptor-Binding Kinetics

A Glycoengineered Interferon-β Mutein (R27T) Generates Prolonged Signaling by an Altered Receptor-Binding Kinetics

The glycoengineering approach is used to improve biophysical properties of protein-based drugs, but its direct impact on binding affinity and kinetic properties for the glycoengineered protein and its binding partner interaction is unclear. Type I interferon (IFN) receptors, composed of IFNAR1 and I...

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Bibliographic Details
Main Authors: Saehyung Lee, Woo Sung Son, Ho Bin Yang, Nirmal Rajasekaran, Sung-Su Kim, Sungyoul Hong, Joon-Seok Choi, Jun Young Choi, Kyoung Song, Young Kee Shin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Pharmacology
Subjects:
interferon-beta
receptor-binding kinetics
Fc-fusion protein
surface plasmon resonance
glycoengineering
multiple sclerosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01568/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.01568/full

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