VEGF Production Is Regulated by the AKT/ERK1/2 Signaling Pathway and Controls the Proliferation of Toxoplasma gondii in ARPE-19 Cells

VEGF Production Is Regulated by the AKT/ERK1/2 Signaling Pathway and Controls the Proliferation of Toxoplasma gondii in ARPE-19 Cells

The retina is the primary site of Toxoplasma gondii infection in the eye, and choroidal neovascularization in ocular toxoplasmosis is one of the most important causes of visual impairment. Vascular endothelial growth factor (VEGF) is one of the key regulators of blood vessel development, however, li...

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Bibliographic Details
Main Authors: Juan-Hua Quan, Hassan Ahmed Hassan Ahmed Ismail, Guang-Ho Cha, Young-Joon Jo, Fei Fei Gao, In-Wook Choi, Jia-Qi Chu, Jae-Min Yuk, Young-Ha Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
ocular toxoplasmosis
retinal pigment epithelium
vascular endothelial growth factor
PI3K/MAPK signaling pathways
Toxoplasma gondii proliferation
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00184/full

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https://www.frontiersin.org/article/10.3389/fcimb.2020.00184/full

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