High-throughput in vivo genotoxicity testing: an automated readout system for the somatic mutation and recombination test (SMART).

Genotoxicity testing is an important component of toxicity assessment. As illustrated by the European registration, evaluation, authorization, and restriction of chemicals (REACH) directive, it concerns all the chemicals used in industry. The commonly used in vivo mammalian tests appear to be ill ad...

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Bibliographic Details
Main Authors: Benoit Lombardot, Chun-Taek Oh, Jihoon Kwak, Auguste Genovesio, Myungjoo Kang, Michael Adsett Edberg Hansen, Sung-Jun Han
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4382174?pdf=render