Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents

Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents

With the goal of obtaining a novel bioactive compound with significant antifungal activity, a series of 1,3,4-thiadiazole derivatives (<b>3a</b>&#8315;<b>3l</b>) were synthesized and characterized. Due to thione-thiol tautomerism in the intermediate compound <b>2<...

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Bibliographic Details
Main Authors: Ahmet Çağrı Karaburun, Ulviye Acar Çevik, Derya Osmaniye, Begüm Nurpelin Sağlık, Betül Kaya Çavuşoğlu, Serkan Levent, Yusuf Özkay, Ali Savaş Koparal, Mustafa Behçet, Zafer Asım Kaplancıklı
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
1,3,4-thiadiazole
thione-thiol tautomerism
docking
antifungal
14-α-sterol demethylase
ADME
Online Access:https://www.mdpi.com/1420-3049/23/12/3129

Internet

https://www.mdpi.com/1420-3049/23/12/3129

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