The Deletion of Endothelial Sodium Channel α (αENaC) Impairs Endothelium-Dependent Vasodilation and Endothelial Barrier Integrity in Endotoxemia in Vivo

The Deletion of Endothelial Sodium Channel α (αENaC) Impairs Endothelium-Dependent Vasodilation and Endothelial Barrier Integrity in Endotoxemia in Vivo

The role of epithelial sodium channel (ENaC) activity in the regulation of endothelial function is not clear. Here, we analyze the role of ENaC in the regulation of endothelium-dependent vasodilation and endothelial permeability in vivo in mice with conditional αENaC subunit gene inactivation in the...

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Bibliographic Details
Main Authors: Magdalena Sternak, Anna Bar, Mateusz G. Adamski, Tasnim Mohaissen, Brygida Marczyk, Anna Kieronska, Marta Stojak, Kamil Kus, Antoine Tarjus, Frederic Jaisser, Stefan Chlopicki
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
αENaC
endothelium
LPS
endothelial-induced vasodilation
endothelial barrier integrity
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00178/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00178/full

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