Microparticles derived from human erythropoietin mRNA-transfected mesenchymal stem cells inhibit epithelial-to-mesenchymal transition and ameliorate renal interstitial fibrosis

Microparticles derived from human erythropoietin mRNA-transfected mesenchymal stem cells inhibit epithelial-to-mesenchymal transition and ameliorate renal interstitial fibrosis

Abstract Background Renal tubulointerstitial fibrosis (TIF) plays an important role in the progression of chronic kidney disease (CKD) and its pathogenesis involves epithelial-to-mesenchymal transition (EMT) upon renal injury. Recombinant human erythropoietin (rhEPO) has been shown to display novel...

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Bibliographic Details
Main Authors: Mirae Lee, Seok-hyung Kim, Jong Hyun Jhee, Tae Yeon Kim, Hoon Young Choi, Hyung Jong Kim, Hyeong Cheon Park
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Stem Cell Research & Therapy
Subjects:
Microparticles
Transforming growth factor-β1
Renal fibrosis
Epithelial-to-mesenchymal transition
Erythropoietin
Online Access:http://link.springer.com/article/10.1186/s13287-020-01932-z

Internet

http://link.springer.com/article/10.1186/s13287-020-01932-z

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