Osteoblast Hypoxia-Inducible Factor-1α Pathway Activation Restrains Osteoclastogenesis via the Interleukin-33-MicroRNA-34a-Notch1 Pathway

Osteoblast Hypoxia-Inducible Factor-1α Pathway Activation Restrains Osteoclastogenesis via the Interleukin-33-MicroRNA-34a-Notch1 Pathway

Functional cross-talk between osteoblasts and osteoclasts is a key process for bone homeostasis. Although osteoblast hypoxia-inducible factor-1α (HIF-1α) pathway activation results in impaired osteoclastogenesis via the direct regulation of osteoprotegerin (OPG), it is unclear whether there are othe...

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Bibliographic Details
Main Authors: Hui Kang, Kai Yang, Lianbo Xiao, Lei Guo, Changjun Guo, Yufei Yan, Jin Qi, Fei Wang, Bernhard Ryffel, Changwei Li, Lianfu Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
hypoxia-inducible factor-1α
interleukin-33
osteoblast
osteoclastogenesis
microRNA-34a-5p
Notch1
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01312/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01312/full

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