Warburg effect's manifestation in aggressive pheochromocytomas and paragangliomas: insights from a mouse cell model applied to human tumor tissue.

Warburg effect's manifestation in aggressive pheochromocytomas and paragangliomas: insights from a mouse cell model applied to human tumor tissue.

A glycolytic profile unifies a group of pheochromocytomas and paragangliomas (PHEOs/PGLs) with distinct underlying gene defects, including von Hippel-Lindau (VHL) and succinate dehydrogenase B (SDHB) mutations. Nevertheless, their tumor aggressiveness is distinct: PHEOs/PGLs metastasize rarely in VH...

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Bibliographic Details
Main Authors: Stephanie M J Fliedner, Nina Kaludercic, Xiao-Sheng Jiang, Hana Hansikova, Zuzana Hajkova, Jana Sladkova, Andrea Limpuangthip, Peter S Backlund, Robert Wesley, Lucia Martiniova, Ivana Jochmanova, Nikoletta K Lendvai, Jan Breza, Alfred L Yergey, Nazareno Paolocci, Arthur S Tischler, Jiri Zeman, Forbes D Porter, Hendrik Lehnert, Karel Pacak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3409208?pdf=render

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http://europepmc.org/articles/PMC3409208?pdf=render

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