Elevated plasma soluble Sema4D/CD100 levels are associated with disease severity in patients of hemorrhagic fever with renal syndrome.

BACKGROUND: Hantaan virus (HTNV) could cause a severe lethal hemorrhagic fever with renal syndrome (HFRS) in humans. Despite a limited understanding of the pathogenesis of HFRS, the importance of host-related immune responses in the pathogenesis of HFRS has been widely recognized. CD100/Sema4D has b...

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Bibliographic Details
Main Authors: Bei Liu, Ying Ma, Jing Yi, Zhuwei Xu, Yu Si Zhang, Chunmei Zhang, Ran Zhuang, Haitao Yu, Jiuping Wang, Angang Yang, Yun Zhang, Boquan Jin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3769313?pdf=render