Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy

Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy

Abstract Background Alpha-synuclein (α-syn) aggregation represents the pathological hallmark of α-synucleinopathies like Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Toll-like receptors (TLRs) are a family of highly conserved molecules that recognize...

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Bibliographic Details
Main Authors: Serena Venezia, Violetta Refolo, Alexia Polissidis, Leonidas Stefanis, Gregor K. Wenning, Nadia Stefanova
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Molecular Neurodegeneration
Subjects:
α-synuclein
Toll-like receptor
Inclusion pathology
Neuroinflammation
Monophosphoryl lipid A
Online Access:http://link.springer.com/article/10.1186/s13024-017-0195-7

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http://link.springer.com/article/10.1186/s13024-017-0195-7

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