Multimodality assessment of heart failure with preserved ejection fraction skeletal muscle reveals differences in the machinery of energy fuel metabolism

Multimodality assessment of heart failure with preserved ejection fraction skeletal muscle reveals differences in the machinery of energy fuel metabolism

Abstract Aims Skeletal muscle (SkM) abnormalities may impact exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF). We sought to quantify differences in SkM oxidative phosphorylation capacity (OxPhos), fibre composition, and the SkM proteome between HFpEF, hyperte...

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Bibliographic Details
Main Authors: Payman Zamani, Elizabeth A. Proto, Neil Wilson, Hossein Fazelinia, Hua Ding, Lynn A. Spruce, Antonio Davila Jr., Thomas C. Hanff, Jeremy A. Mazurek, Stuart B. Prenner, Benoit Desjardins, Kenneth B. Margulies, Daniel P. Kelly, Zoltan Arany, Paschalis‐Thomas Doulias, John W. Elrod, Mitchell E. Allen, Shana E. McCormack, Gayatri Maria Schur, Kevin D'Aquilla, Dushyant Kumar, Deepa Thakuri, Karthik Prabhakaran, Michael C. Langham, David C. Poole, Steven H. Seeholzer, Ravinder Reddy, Harry Ischiropoulos, Julio A. Chirinos
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:ESC Heart Failure
Subjects:
HFpEF
Exercise
Skeletal muscle
Online Access:https://doi.org/10.1002/ehf2.13329

Internet

https://doi.org/10.1002/ehf2.13329

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