Cystathionine beta synthase deficiency and brain edema associated with methionine excess under betaine supplementation: Four new cases and a review of the evidence

Cystathionine beta synthase deficiency and brain edema associated with methionine excess under betaine supplementation: Four new cases and a review of the evidence

Abstract CBS deficient individuals undergoing betaine supplementation without sufficient dietary methionine restriction can develop severe hypermethioninemia and brain edema. Brain edema has also been observed in individuals with severe hypermethioninemia without concomitant betaine supplementation....

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Bibliographic Details
Main Authors: Bernd C. Schwahn, Thomas Scheffner, Hedwig Stepman, Peter Verloo, Anibh M Das, Janice Fletcher, Henk J Blom, Jean‐Francois Benoist, Bruce A. Barshop, Jaime J. Barea, Annette Feigenbaum
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:JIMD Reports
Subjects:
adverse drug effect
betaine
brain edema
CBS deficiency
encephalopathy
homocystinuria
Online Access:https://doi.org/10.1002/jmd2.12092

Internet

https://doi.org/10.1002/jmd2.12092

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