Postictal behavioural impairments are due to a severe prolonged hypoperfusion/hypoxia event that is COX-2 dependent

Postictal behavioural impairments are due to a severe prolonged hypoperfusion/hypoxia event that is COX-2 dependent

Seizures are often followed by sensory, cognitive or motor impairments during the postictal phase that show striking similarity to transient hypoxic/ischemic attacks. Here we show that seizures result in a severe hypoxic attack confined to the postictal period. We measured brain oxygenation in local...

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Bibliographic Details
Main Authors: Jordan S Farrell, Ismael Gaxiola-Valdez, Marshal D Wolff, Laurence S David, Haruna I Dika, Bryce L Geeraert, X Rachel Wang, Shaily Singh, Simon C Spanswick, Jeff F Dunn, Michael C Antle, Paolo Federico, G Campbell Teskey
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
epilepsy
seizures
hypoxia
hypoperfusion
behavioural dysfunction
Online Access:https://elifesciences.org/articles/19352

Internet

https://elifesciences.org/articles/19352

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