Exploring the pre-immune landscape of antigen-specific T cells

Exploring the pre-immune landscape of antigen-specific T cells

Abstract Background Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells. Using recent advances in immune repertoire sequencing technologies, models of the immune receptor rearrangement process,...

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Bibliographic Details
Main Authors: Mikhail V. Pogorelyy, Alla D. Fedorova, James E. McLaren, Kristin Ladell, Dmitri V. Bagaev, Alexey V. Eliseev, Artem I. Mikelov, Anna E. Koneva, Ivan V. Zvyagin, David A. Price, Dmitry M. Chudakov, Mikhail Shugay
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Genome Medicine
Subjects:
Antigen
Immune repertoire
Immunogenicity
T cell receptor
Online Access:http://link.springer.com/article/10.1186/s13073-018-0577-7

Internet

http://link.springer.com/article/10.1186/s13073-018-0577-7

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