Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells

Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells

LIF promotes self-renewal of mouse embryonic stem cells (mESCs), and in its absence, the cells differentiate. LIF binds to the LIF receptor (LIFR) and activates the JAK-STAT3 pathway, but it remains unknown how the receptor complex triggers differentiation or self-renewal. Here, we report that the L...

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Bibliographic Details
Main Authors: Xiong-jun Wang, Yunbo Qiao, Minzhe M. Xiao, Lingbo Wang, Jun Chen, Wenjian Lv, Li Xu, Yan Li, Yumei Wang, Ming-dian Tan, Chao Huang, Jinsong Li, Ting C. Zhao, Zhaoyuan Hou, Naihe Jing, Y. Eugene Chin
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
STAT3
embryonic stem cells
self-renewal
differentiation
MAPK
acetylation
phosphorylation
signaling
LIF
LIFR
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716318034

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http://www.sciencedirect.com/science/article/pii/S2211124716318034

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