YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion.

YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion.

Genomic rearrangements involving the ETS family of transcription factors occur in 40-70% of prostate cancer cases. ERG and ETV1 are the most common ETS members observed in these genetic alterations. The high prevalence of these rearrangements and their biological significance represents a novel ther...

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Bibliographic Details
Main Authors: Said Rahim, Elspeth M Beauchamp, Yali Kong, Milton L Brown, Jeffrey A Toretsky, Aykut Üren
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3084826?pdf=render

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http://europepmc.org/articles/PMC3084826?pdf=render

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