Toxicity of a combined therapy using the mTOR-inhibitor everolimus and PRRT with [177Lu]Lu-DOTA-TATE in Lewis rats

Toxicity of a combined therapy using the mTOR-inhibitor everolimus and PRRT with [177Lu]Lu-DOTA-TATE in Lewis rats

Abstract Purpose Peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTA0,TYR3-octreotate ([177Lu]Lu-DOTA-TATE) and the mechanistic target of rapamycin (mTOR) inhibitor everolimus are both approved for the treatment of neuroendocrine tumours (NET). However, tumour progression is still frequ...

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Bibliographic Details
Main Authors: Johannes Zellmer, Hsi-Yu Yen, Lena Kaiser, Erik Mille, Franz Josef Gildehaus, Guido Böning, Katja Steiger, Marcus Hacker, Peter Bartenstein, Andrei Todica, Alexander R. Haug, Harun Ilhan
Format: Article
Language:English
Published: SpringerOpen 2020-04-01
Series:EJNMMI Research
Subjects:
[177Lu]Lu-DOTA-TATE
PRRT
Everolimus
Scintigraphy
Renal clearance
Online Access:http://link.springer.com/article/10.1186/s13550-020-00628-y

Internet

http://link.springer.com/article/10.1186/s13550-020-00628-y

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