Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function

Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function

Shuttling RNA-binding proteins coordinate nuclear and cytoplasmic steps of gene expression. The SR family proteins regulate RNA splicing in the nucleus and a subset of them, including SRSF1, shuttles between the nucleus and cytoplasm affecting post-splicing processes. However, the physiological sign...

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Bibliographic Details
Main Authors: Fiona Haward, Magdalena M Maslon, Patricia L Yeyati, Nicolas Bellora, Jan N Hansen, Stuart Aitken, Jennifer Lawson, Alex von Kriegsheim, Dagmar Wachten, Pleasantine Mill, Ian R Adams, Javier F Caceres
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
SR proteins
SRSF1
RNA-binding proteins
alternative splicing
mRNA translation
motile cilia
Online Access:https://elifesciences.org/articles/65104

Internet

https://elifesciences.org/articles/65104

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