Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis.

Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis.

Although in cirrhosis with portal hypertension levels of the vasoconstrictor angiotensin II are increased, this is accompanied by increased production of angiotensin (Ang)-(1-7), the endogenous ligand of the Mas receptor (MasR), which blunts hepatic fibrosis and decreases hepatic vascular resistance...

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Bibliographic Details
Main Authors: Sabine Klein, Chandana B Herath, Robert Schierwagen, Josephine Grace, Tom Haltenhof, Frank E Uschner, Christian P Strassburg, Tilman Sauerbruch, Thomas Walther, Peter W Angus, Jonel Trebicka
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4583473?pdf=render

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http://europepmc.org/articles/PMC4583473?pdf=render

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