Genetic and Epigenetic Perturbations by DNMT3A-R882 Mutants Impaired Apoptosis through Augmentation of PRDX2 in Myeloid Leukemia Cells

Genetic and Epigenetic Perturbations by DNMT3A-R882 Mutants Impaired Apoptosis through Augmentation of PRDX2 in Myeloid Leukemia Cells

DNA methyltransferase 3A (DNMT3A) is mutated in various myeloid neoplasms including acute myeloid leukemia (AML), especially at the Arg882 and associated with inferior outcomes. Here, we report that the DNMT3A-Arg882His/Cys (R882H/C) mutations led to inactivation of apoptosis through DNA damage sign...

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Bibliographic Details
Main Authors: Rabindranath Bera, Ming-Chun Chiu, Ying-Jung Huang, Der-Cherng Liang, Yun-Shien Lee, Lee-Yung Shih
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558618301398

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http://www.sciencedirect.com/science/article/pii/S1476558618301398

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