Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families

Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families

Abstract Background In the majority of familial breast cancer (BC) families, the etiology of the disease remains unresolved. To identify missing BC heritability resulting from relatively rare variants (minor allele frequency ≤ 1%), we have performed whole exome sequencing followed by variant analysi...

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Bibliographic Details
Main Authors: Rajendra Bahadur Shahi, Sylvia De Brakeleer, Ben Caljon, Ingrid Pauwels, Maryse Bonduelle, Sofie Joris, Christel Fontaine, Marian Vanhoeij, Sonia Van Dooren, Erik Teugels, Jacques De Grève
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Cancer
Subjects:
Familial breast cancer
Missing heritability
BRCA1 and BRCA2-negative
Whole exome sequencing
Candidate breast cancer predisposing genes/variants
Online Access:http://link.springer.com/article/10.1186/s12885-019-5494-7

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http://link.springer.com/article/10.1186/s12885-019-5494-7

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