Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer

Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer

Abstract Background Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive and lethal disease, lacking effective therapeutic approaches. Available therapies only marginally prolong patient survival and are frequently coupled with severe adverse events. It is therefore pivotal to investigate novel...

Full description

Bibliographic Details
Main Authors: Aleksandra Adamska, Alice Domenichini, Emily Capone, Verena Damiani, Begum Gokcen Akkaya, Kenneth J. Linton, Pierluigi Di Sebastiano, Xi Chen, Adam B. Keeton, Veronica Ramirez-Alcantara, Yulia Maxuitenko, Gary A. Piazza, Vincenzo De Laurenzi, Gianluca Sala, Marco Falasca
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic ductal adenocarcinoma
ABC transporters
ABCC3
PDAC therapy
Tumour stroma
Online Access:http://link.springer.com/article/10.1186/s13046-019-1308-7

Internet

http://link.springer.com/article/10.1186/s13046-019-1308-7

Similar Items