Pre-clinical assessment of a water-in-fluorocarbon emulsion for the treatment of pulmonary vascular diseases

Pre-clinical assessment of a water-in-fluorocarbon emulsion for the treatment of pulmonary vascular diseases

Hypoxic pulmonary vasoconstriction (HPV) is a well-characterized vascular response to low oxygen pressures and is involved in life-threatening conditions such as high-altitude pulmonary edema (HAPE) and pulmonary arterial hypertension (PAH). While the efficacy of oral therapies can be affected by dr...

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Bibliographic Details
Main Authors: Scott K. Ferguson, David I. Pak, Justin L. Hopkins, Julie W. Harral, Katherine M. Redinius, Zoe Loomis, Kurt R. Stenmark, Mark A. Borden, Thies Schroeder, David C. Irwin
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Drug Delivery
Subjects:
pulmonary hypertension
pulmonary pressures
high altitude pulmonary edema
endothelin
ambrisentan
sodium nitrite
perfluorocarbon
Online Access:http://dx.doi.org/10.1080/10717544.2019.1568621

Internet

http://dx.doi.org/10.1080/10717544.2019.1568621

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