Designing and Characterization of a Novel Delivery System for Improved Cellular Uptake by Brain Using Dendronised Apo-E-Derived Peptide

Designing and Characterization of a Novel Delivery System for Improved Cellular Uptake by Brain Using Dendronised Apo-E-Derived Peptide

Neurodegenerative diseases (ND) are characterized by the progressive loss of neuronal structure or function mostly associated with neuronal death. The presence of the blood–brain barrier (BBB) is considered the main obstacle that prevents the penetration of almost all drugs rendering the diseases un...

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Bibliographic Details
Main Authors: Shafq Al-azzawi, Dhafir Masheta, Anna Guildford, Gary Phillips, Matteo Santin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
neurodegenerative disease
blood-brain barrier
dendrimers
drug delivery system
cellular uptake
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00049/full

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https://www.frontiersin.org/article/10.3389/fbioe.2019.00049/full

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