Dihydroartemisinin Inhibits mTORC1 Signaling by Activating the AMPK Pathway in Rhabdomyosarcoma Tumor Cells

Dihydroartemisinin Inhibits mTORC1 Signaling by Activating the AMPK Pathway in Rhabdomyosarcoma Tumor Cells

Dihydroartemisinin (DHA), an anti-malarial drug, has been shown to possess potent anticancer activity, partly by inhibiting the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) signaling. However, how DHA inhibits mTORC1 is still unknown. Here, using rhabdomyosarcoma (RMS) as a model, we foun...

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Bibliographic Details
Main Authors: Jun Luo, Yoshinobu Odaka, Zhu Huang, Bing Cheng, Wang Liu, Lin Li, Chaowei Shang, Chao Zhang, Yang Wu, Yan Luo, Shengyong Yang, Peter J. Houghton, Xiaofeng Guo, Shile Huang
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
dihydroartemisinin
rhabdomyosarcoma
mTOR
AMPK
PTEN
raptor
Online Access:https://www.mdpi.com/2073-4409/10/6/1363

Internet

https://www.mdpi.com/2073-4409/10/6/1363

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