Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development

By performing ATAC-Seq on zebrafish melanoma tumours, Cunningham et al identify putative sox10 enhancers with embryonic activity in zebrafish. They identify a region upstream of sox10, termed peak5, that is needed for full expression of embryonic sox10 and for adult stripe patterning demonstrating a...

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Bibliographic Details
Main Authors: Rebecca L. Cunningham, Eva T. Kramer, Sophia K. DeGeorgia, Paula M. Godoy, Anna P. Zarov, Shayana Seneviratne, Vadim Grigura, Charles K. Kaufman
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02211-0