Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

Summary: Human cardiac regeneration is limited by low cardiomyocyte replicative rates and progressive polyploidization by unclear mechanisms. To study this process, we engineer a human cardiomyocyte model to track replication and polyploidization using fluorescently tagged cyclin B1 and cardiac trop...

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Bibliographic Details
Main Authors: Anthony M. Pettinato, Dasom Yoo, Jennifer VanOudenhove, Yu-Sheng Chen, Rachel Cohn, Feria A. Ladha, Xiulan Yang, Ketan Thakar, Robert Romano, Nicolas Legere, Emily Meredith, Paul Robson, Michael Regnier, Justin L. Cotney, Charles E. Murry, J. Travis Hinson
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports
Subjects:
sarcomere
cardiomyocytes
P53
single-cell genomics
cell cycle
cardiac regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721004216

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http://www.sciencedirect.com/science/article/pii/S2211124721004216

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