Valproic acid sensitizes metformin-resistant human renal cell carcinoma cells by upregulating H3 acetylation and EMT reversal

Valproic acid sensitizes metformin-resistant human renal cell carcinoma cells by upregulating H3 acetylation and EMT reversal

Abstract Background Metformin (Met) is a widely available diabetic drug and shows suppressed effects on renal cell carcinoma (RCC) metabolism and proliferation. Laboratory studies in RCC suggested that metformin has remarkable antitumor activities and seems to be a potential antitumor drug. But the...

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Bibliographic Details
Main Authors: Muyun Wei, Shaowei Mao, Guoliang Lu, Liang Li, Xiaopeng Lan, Zhongxian Huang, Yougen Chen, Miaoqing Zhao, Yueran Zhao, Qinghua Xia
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Cancer
Subjects:
Metformin
Valproic acid
Histone H3
EMT
Resistance
Online Access:http://link.springer.com/article/10.1186/s12885-018-4344-3

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http://link.springer.com/article/10.1186/s12885-018-4344-3

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