Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage

Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage

Oligodendrocytes derive from progenitors (OPCs) through the interplay of epigenomic and transcriptional events. By integrating high-resolution methylomics, RNA-sequencing, and multiple transgenic lines, this study defines the role of DNMT1 in developmental myelination. We detected hypermethylation o...

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Bibliographic Details
Main Authors: Sarah Moyon, Jimmy L. Huynh, Dipankar Dutta, Fan Zhang, Dan Ma, Seungyeul Yoo, Rebecca Lawrence, Michael Wegner, Gareth R. John, Ben Emery, Catherine Lubetzki, Robin J.M. Franklin, Guoping Fan, Jun Zhu, Jeffrey L. Dupree, Patrizia Casaccia
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471630331X

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http://www.sciencedirect.com/science/article/pii/S221112471630331X

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